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SML2090

Sigma-Aldrich

NAMI-A

≥98% ruthenium (Ru) basis (elemental analysis)

Synonyme(s) :

1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-κN3)[1,1′-(sulfinyl-κS)bis[methane]]ruthenate(1-) (1:1), ImH[trans-RuCl4(DMSO)Im], Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate

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About This Item

Formule empirique (notation de Hill):
C5H10Cl4N2ORuS · C3H5N2
Numéro CAS:
Poids moléculaire :
458.18
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Pureté

≥98% ruthenium (Ru) basis (elemental analysis)

Forme

powder

Conditions de stockage

desiccated

Couleur

faint red to dark brown

Solubilité

H2O: 2 mg/mL, clear

Température de stockage

−20°C

Chaîne SMILES 

CS(C)=O.Cl[Ru](Cl)(Cl)Cl.N1=CNC=C1.C2=[NH+]C=CN2

Actions biochimiques/physiologiques

NAMI-A is a potent antimetastatic drug in vivo that is exhibits little cytotoxicity towards many cancer cell lines. Antimetastatic of NAMI-A is attributed to the formation of adducts with membrane and cytosolic proteins. Nevertheless NAMI-A induces potent and selective cytotoxic effects in several leukemia cell lines. NAMI-A exhibits low toxicity for host tissues.
NAMI-A is a ruthenium-based anticancer agent.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

K Śpiewak et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(4), 695-703 (2015-03-21)
Imidazolium trans-tetrachloridodimethylsulfoxideimidazolruthenate(III), NAMI-A, a novel antimetastatic ruthenium complex was investigated towards affinity to transferrin (Tf), whether Tf-Ru adducts might be formed after its intravenous injection. Studies were focused on the holotransferrin due to its preferential binding to transferrin receptor. Here
Serena Pillozzi et al.
Dalton transactions (Cambridge, England : 2003), 43(32), 12150-12155 (2014-07-01)
We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic"
Alberta Bergamo et al.
Journal of inorganic biochemistry, 168, 90-97 (2017-01-09)
Solid tumours are constituted of tumour cells, healthy cells recruited from the host tissues and soluble factors released by both these cell types. The present investigation examines the capacity of co-cultures between the HCEC colon epithelial cells and the HCT-116
Metal-DNA coordination complexes
Pizarro AM, et al.
3D printing and additive manufacturing (2013)

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