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SCP0091

Sigma-Aldrich

Caspase 9 Substrate, chromogenic

≥95% (HPLC), lyophilized

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About This Item

Formule empirique (notation de Hill):
C29H38N8O11
Poids moléculaire :
674.66
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

product name

Caspase 9 Substrate, chromogenic, ≥95% (HPLC)

Pureté

≥95% (HPLC)

Forme

lyophilized

Composition

Peptide Content, ≥75%

Conditions de stockage

protect from light

Température de stockage

−20°C

Amino Acid Sequence

Ac-Leu-Glu-His-Asp-pNA

Application

Caspase 9 is an initiator caspase that cleaves procaspase 3 and procaspase 7 to propagate the apoptotic cascade. Caspase 9 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the LEHD peptide core such as the chromogenic substrate Ac-LEHD-pNa (Ac-Leu-Glu-His-Asp-p-nitroanalide).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Lin-Li Zhou et al.
European journal of pharmacology, 670(2-3), 399-408 (2011-09-29)
Psoriasis is a chronic inflammatory skin disease affecting 1-3% of the world's population. Traditional Chinese medicines have been extensively used for treating psoriasis with promising clinical results. Celastrol, a triterpenoid isolated from a Chinese herb Celastrus orbiculatus caulis, has been
Juan Liu et al.
Molecular cancer, 10, 95-95 (2011-08-02)
Caspase-8 is a key upstream mediator in death receptor-mediated apoptosis and also participates in mitochondria-mediated apoptosis via cleavage of proapoptotic Bid. However, the role of caspase-8 in p53- and p73-dependent apoptosis induced by genotoxic drugs remains unclear. We recently reported
Yinyuan Wu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 27(5), 539-546 (2011-06-22)
Oxidative stress is known to be involved in a variety of pathological processes including atherosclerosis, diabetes, and neurodegenerative diseases. Understanding how intracellular signaling pathways respond to oxidative stress will have a significant implication in the therapy of these diseases. In
Aza-derivatives of resveratrol are potent macrophage migration inhibitory factor inhibitors.
Fujita, Y., et al.
Investigational New Drugs (2011)
Sriram Ravindran et al.
Journal of biochemical and molecular toxicology, 34(12), e22606-e22606 (2020-09-01)
One of the common negative impacts in the management of acute myocardial infarction is cognitive decline. Using the rat model of isoproterenol (ISO)-induced myocardial infarction, we assessed the cardioprotective effect of sodium thiosulfate (STS) and its influence on cognition. STS

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