SBR00032
MIT HCl Ready Made Solution
95 mg/mL in water (9.5%)
Synonyme(s) :
2-Methyl-1,2-thiazol-3-one, Methylisothiazolinone HCl, Methylisothiazolinone hydrochloride
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About This Item
Code UNSPSC :
51102829
Nomenclature NACRES :
NA.76
Produits recommandés
Forme
liquid
Niveau de qualité
Concentration
95 mg/mL in water (9.5%)
Spectre d'activité de l'antibiotique
Gram-negative bacteria
Gram-positive bacteria
Mode d’action
protein synthesis | interferes
Température de stockage
2-8°C
InChI
1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
Clé InChI
SJXPQSRCFCPWQQ-UHFFFAOYSA-N
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Description générale
Methylisothiazolinone, also known as 2-Methyl-4-isothiazolin-3-one, is a potent synthetic biocide and preservative belonging to the group of isothiazolinones. It effectively controls microbial growth and acts as a broad-spectrum antibiotic, similar to the function and performance of bromonitrodioxane. It is effective against both gram-positive and gram-negative bacteria, as well as yeast and fungi. Additionally, it serves as an antifouling biocide, an antimicrobial agent, and an antifungal agent. 2-Methyl-4-isothiazolin-3-one is utilized in microbiology and cell biology applications to effectively prevent the growth of bacterial contaminants, ensuring the purity of cell lines.
Application
Methylisothiazolinone (MIT) has been used:
- in research on the effects of the N-methyl D-aspartate (NMDA) receptor antagonist kynurenic acid on human cortical development [1]
- as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and role in apoptotic cell death(2)
- to research the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites(3)
Actions biochimiques/physiologiques
Mode of Action: Inhibits the growth of microorganisms by disrupting the normal function of microbial cells and interferes with essential cellular processes.
Activity Spectrum: Active against Gram-positive and Gram-negative bacteria, as well as fungi, when used in combination with methylchloroisothiazolinone (MCI)
Activity Spectrum: Active against Gram-positive and Gram-negative bacteria, as well as fungi, when used in combination with methylchloroisothiazolinone (MCI)
Caractéristiques et avantages
- Ready available solution reduce the need for preparation time
- Commonly used in Cell Biology and Biochemical applications
- High quality antibiotic suitable for mulitple research applications
Autres remarques
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Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1
Risques supp
Code de la classe de stockage
8B - Non-combustible corrosive hazardous materials
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Zhengxi Wei et al.
Toxicology letters, 338, 67-77 (2020-12-09)
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic
Shen Du et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17), 7408-7416 (2002-08-28)
Neurodegenerative disorders in humans may be triggered or exacerbated by exposure to occupational or environmental agents. Here, we show that a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons but not
Eun-Jung Park et al.
Toxicology in vitro : an international journal published in association with BIBRA, 62, 104661-104661 (2019-10-21)
Methylisothiazolinone (MIT) has been used in wide spectrum of fields due to its ability to inhibit microbial proliferation with low toxicity. Meanwhile, in Korea, the concern about the hazardous effects of MIT was amplified by the occurrence of patients that
Erol Capkin et al.
Chemosphere, 182, 720-729 (2017-05-23)
Triclosan (TRC), chloroxylenol (PCMX) and methylisothiazolinone (MIT) have been commonly used as an antimicrobial in soaps while borax (BRX) is used in household cleaning. After using these chemicals, they are washed down drains and getting into the aquatic ecosystem in
M D Lundov et al.
The British journal of dermatology, 165(6), 1178-1182 (2011-07-23)
In the early 2000s the preservative methylisothiazolinone (MI) was released as an individual preservative for industrial products and, in 2005, it was permitted for use in cosmetic products. Up until then MI had been used only in combination with methylchloroisothiazolinone
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