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SAE0112

Sigma-Aldrich

β2-Microglobulin from human urine

≥98% (SDS-PAGE), solution

Synonyme(s) :

β2-Microglobulin from human urine

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About This Item

Numéro MDL:
MFCD00130615
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Source biologique

human

Pureté

≥98% (SDS-PAGE)

Forme

solution

Impuretés

Infectious Agents, tested

Solubilité

water: soluble

Numéro d'accès UniProt

P61769

Température de stockage

2-8°C

Informations sur le gène

human ... B2M(567)

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Description générale

Research area: Cancer

β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. It is a non-glycosylated protein, synthesized by all nucleated cells. Its secondary structure comprises of seven β-strands, arranged into two β-sheets connected by a single disulfide bridge.

Application

β2-Microglobulin from human urine was used to test humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia. It was also used in the identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

Actions biochimiques/physiologiques

The interaction of β2 microglobulin (β2-M) with major histocompatibility complex (MHC) is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8+ cells. A transient complex of MHC heavy chain and β2-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-M complex to the cell surface. Absence of binding leads to degradation in the proteasome. β2-M serves as a regulator of cell survival, proliferation, migration, invasion, apoptosis, angiogenesis, and metastasis in cancer cells. It is also recognized for promoting the growth and survival of stromal cells, such as mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, thereby supporting cancer bone metastasis.

Notes préparatoires

Prepared by the method of Berggard and Bearn.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

?2-Microglobulin: emerging as a promising cancer therapeutic target
Shi C, et al.
Drug Discovery Today, 14(1-2), 25-30 (2009)
The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator
Li L, et al.
Chinese Medical Journal (English Edition), 129(4), 448-455 (2016)
?2-Microglobulin-mediated Signaling as a Target for Cancer Therapy
Nomura T, et al.
Anticancer Agents in Medicinal Chemistry, 14(3), 343?352-343?352 (2014)

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