SAB4501396
Anti-ACC1 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
ACAC, ACACA, ACC-α, ACCA, Acetyl-CoA carboxylase 1
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 265 kDa
Espèces réactives
rat, human, mouse
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... ACACA(31)
Description générale
Anti-ACC1 Antibody detects endogenous levels of total ACC1 protein.
Acetyl-CoA carboxylase 1 (ACC1) is expressed in adipose tissue, liver, and lactating mammary gland. It is a cytosolic enzyme. The ACC1 gene is mapped to human chromosome 17q12. It comprises biotin carboxylase (BC), carboxyl transferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The BC and CT domains are bridged together through an interaction domain (BT) and a non-catalytic central domain region (CD). The ACC1 gene encompasses three distinct promoter (PI, PII, and PIII) regions.
Immunogène
The antiserum was produced against synthesized peptide derived from human ACC1.
Immunogen Range: 46-95
Immunogen Range: 46-95
Application
Anti-ACC1 antibody produced in rabbit has been used in immunoblotting at a dilution 1:500 and immunohistochemistry (1:50 dilution).
Actions biochimiques/physiologiques
Acetyl-CoA carboxylase 1 (ACC1) mediates the carboxylation of acetyl-CoA to form malonyl-CoA in an ATP-dependent manner. It plays a key role in lipogenesis, and its inhibition is regarded as one of the ways to target fatty acid synthesis, especially in metabolic disorders and metabolic syndromes. Haploinsufficiency of ACC1 gene impacts regular fatty acid metabolism. This, in turn, may lead to pathologies associated with infantile encephalitic illness and seizures.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Claudia Tonini et al.
Nutrients, 13(6) (2021-07-03)
Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate from dermal contact. In over 90% of individuals, including pregnant women, BPA is detectable in
Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses
Tonini C, et al.
Nutrients null
Moritz Hunkeler et al.
Nature, 558(7710), 470-474 (2018-06-15)
Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis1,2. Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is anchored to the
Krishna B Singh et al.
Molecular cancer therapeutics, 18(10), 1800-1810 (2019-08-10)
Increased de novo synthesis of fatty acids is implicated in the pathogenesis of human prostate cancer, but a safe and effective clinical inhibitor of this metabolic pathway is still lacking. We have shown previously that leelamine (LLM) suppresses transcriptional activity
Fabrizio Damiano et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(4), 388-398 (2018-01-19)
Acetyl-CoA carboxylase 1 (ACC1) is a cytosolic enzyme catalyzing the rate limiting step in de novo fatty acid biosynthesis. There is mounting evidence showing that ACC1 is susceptible to dysregulation and that it is over-expressed in liver diseases associated with
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