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SAB4500435

Sigma-Aldrich

Anti-Claudin 3 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CPE-R 2, CPE-receptor 2, Claudin-3, Clostridium perfringens enterotoxin receptor 2, Ventral prostate.1 protein homolog

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 23 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

O15551

Numéro d'accès UniProt

O15551

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CLDN3(1365)

Catégories apparentées

Description générale

Anti-Claudin 3 Antibody detects endogenous levels of total Claudin 3 protein.
Claudin-3 (CLDN3) is a tetraspanin transmembrane protein, that is mapped to human chromosome 7q11.23.

Immunogène

The antiserum was produced against synthesized peptide derived from human Claudin 3.

Immunogen Range: 171-220

Application

Anti-Claudin 3, C-Terminal antibody has been used in immunofluorescence and western blotting.

Actions biochimiques/physiologiques

In submandibular gland, claudin-3 (CLDN3) controls paracellular permeability with the help of TNF-α(tumor necrosis factor α). High level expression of CLDN3 improves the malignant ability of colorectal cancer cells. It participates in the organization and activities of tight junctions (TJs).

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells
Ando H, et al.
Bioscience, Biotechnology, and Biochemistry, 79(8), 1272-1279 (2015)
Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling
de Souza WF, et al.
PLoS ONE (2013)
Claudin-3 is required for modulation of paracellular permeability by TNF-? through ERK1/2/slug signaling axis in submandibular gland
Mei M, et al.
Cellular Signalling, 27(10), 1915-1927 (2015)
Katharina M C Klee et al.
Human genetics, 139(10), 1247-1259 (2020-04-20)
Congenital diarrheal disorders (CDD) comprise > 50 monogenic entities featuring chronic diarrhea of early-onset, including defects in nutrient and electrolyte absorption, enterocyte polarization, enteroendocrine cell differentiation, and epithelial integrity. Diarrhea is also a predominant symptom in many immunodeficiencies, congenital disorders of glycosylation
Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel
Wilmes A, et al.
Toxicology and Applied Pharmacology, 279(2), 163-172 (2014)
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