SAB4301310

Anti-phospho-PEK/PERK (pThr⁹⁸¹) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : E2AK3, EIF2AK3, PEK, PERK
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 125 kDa
• Espèces réactives: human
• Concentration: 1.0 mg/mL
• Technique(s): immunohistochemistry: 1:50-1:100
• Isotype: IgG
• Numéro d'accès: NP_004827.4.
• Numéro d'accès UniProt: Q9NZJ5
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pThr981)
• Informations sur le gène: human ... EIF2AK3(9451)

Description

Description générale

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)/EIF2AK3 (eukaryotic translation initiation factor 2 α kinase 3) is a type I transmembrane protein, located on ER (endoplasmic reticulum). It is a member of the eIF2α kinase subfamily. This gene is located on human chromosome 2p. EIF2AK3 has 16 exons and is made of cytoplasmic and kinase domains.

Spécificité

The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.

Immunogène

Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK.

Actions biochimiques/physiologiques

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) helps to detect the protein-folding imbalance created by endoplasmic reticulum (ER) stress. EIF2AK3 works as an endoplasmic reticulum (ER) stress sensor to modulate global protein synthesis. Mutation in EIF2AK3 gene results in Wolcott-rallison syndrome.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable