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S4441

Sigma-Aldrich

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

Synonyme(s) :

1-Isothiocyanato-4-(methylsulfinyl)-butane

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About This Item

Formule empirique (notation de Hill):
C6H11NOS2
Numéro CAS:
4478-93-7
Poids moléculaire :
177.29
Numéro MDL:
MFCD00198068
Code UNSPSC :
12352200
ID de substance PubChem :
24724610
Nomenclature NACRES :
NA.77

product name

DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid

Source biologique

synthetic

Pureté

≥90% (HPLC)

Forme

liquid

Solubilité

DMSO: soluble 40 mg/mL
H2O: insoluble

Compatibilité

for use with ABI 7500

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CS(=O)CCCCN=C=S

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3

Clé InChI

SUVMJBTUFCVSAD-UHFFFAOYSA-N

Application

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Actions biochimiques/physiologiques

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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