P5396

Phosphomycin disodium salt

antibacterial MurA inhibitor

• Synonyme(s) : (−)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphonomycin
• Formule empirique (notation de Hill): C₃H₅Na₂O₄P
• Poids moléculaire : 182.02
• Numéro Beilstein : 4604425
• Numéro CE : 247-409-2
• Numéro MDL: MFCD22741288
• Code UNSPSC : 51102829
• ID de substance PubChem : 24278640
• Nomenclature NACRES : NA.85

Propriétés

• Niveau de qualité: 200
• Forme: powder
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: cell wall synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: [Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
• InChI: 1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
• Clé InChI: QZIQJIKUVJMTDG-JSTPYPERSA-L

Description

Application

Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine.

Actions biochimiques/physiologiques

Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.

Autres remarques

1g,5g,50g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)