P4498

Pravastatin sodium salt hydrate

≥98% (HPLC), powder

• Synonyme(s) : (βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate
• Formule empirique (notation de Hill): C₂₃H₃₅O₇Na · xH₂O
• Numéro CAS: 81131-70-6
• Poids moléculaire : 446.51 (anhydrous basis)
• Numéro MDL: MFCD00887601
• Code UNSPSC : 12352200
• ID de substance PubChem : 329820206
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Pf: 171.2-173 °C
• Solubilité: H₂O: >10 mg/mL
• Auteur: Bristol-Myers Squibb
• Température de stockage: 2-8°C
• Chaîne SMILES: [Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O
• InChI: 1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
• Clé InChI: VWBQYTRBTXKKOG-IYNICTALSA-M
• Informations sur le gène: human ... HMGCR(3156)

Description

Description générale

Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.

Application

Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.

Actions biochimiques/physiologiques

Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).

Caractéristiques et avantages

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)