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P1138

Sigma-Aldrich

1,2-Distearoyl-sn-glycero-3-phosphocholine

≥99%

Synonyme(s) :

PC, 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1,2-distearoyl, L-α-Phosphatidylcholine, distearoyl, L-β,γ-Distearoyl-α-lecithin, DSPC, PC(18:0/18:0)

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About This Item

Formule empirique (notation de Hill):
C44H88NO8P
Numéro CAS:
816-94-4
Poids moléculaire :
790.15
Numéro Beilstein :
3923978
Numéro CE :
212-440-2
Numéro MDL:
MFCD00036905
Code UNSPSC :
12352211
ID de substance PubChem :
24898160
Nomenclature NACRES :
NA.25

Source biologique

semisynthetic

Pureté

≥99%

Forme

powder

Groupe fonctionnel

phospholipid

Type de lipide

phosphoglycerides

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

Clé InChI

NRJAVPSFFCBXDT-HUESYALOSA-N

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Description générale

Non-pyrogenic, well-defined liposomes, loaded with a molecule of choice, are formed by a single hydration step.

Application


  • Amantadine interactions with phase separated lipid membranes.: This study explores the interactions between amantadine and phase-separated lipid membranes, providing insights into the role of 1,2-Distearoyl-sn-glycero-3-phosphocholine in membrane structure and function (Kinnun et al., 2024).

  • Design of charge converting lipid nanoparticles via a microfluidic coating technique.: This research designs lipid nanoparticles with charge-converting capabilities using 1,2-Distearoyl-sn-glycero-3-phosphocholine, enhancing drug delivery systems (Zöller et al., 2024).

  • Investigation and Comparison of Active and Passive Encapsulation Methods for Loading Proteins into Liposomes.: The study compares methods for protein encapsulation into liposomes using 1,2-Distearoyl-sn-glycero-3-phosphocholine, advancing drug delivery technologies (Pisani et al., 2023).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Sigma-Aldrich

P1263

1,2-Didodecanoyl-sn-glycero-3-phosphocholine

Mette Marie Bruun Nielsen et al.
Langmuir : the ACS journal of surfaces and colloids, 29(5), 1525-1532 (2013-01-04)
Imaging ellipsometry (IE) has been applied to generate laterally resolved thickness maps of spin-coated membranes in both the dry and fully hydrated state. Spin-coating offers a convenient preparation method for stacked supported membranes, and in-depth thickness maps for such films
Hiroyuki Nakamura et al.
Organic & biomolecular chemistry, 10(7), 1374-1380 (2011-12-24)
The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent
Xiaoming Xu et al.
International journal of pharmaceutics, 423(2), 410-418 (2011-12-31)
A mathematical model has been developed to predict the encapsulation efficiency of hydrophilic drugs in unilamellar liposomes, and will be useful in formulation development to rapidly achieve optimized formulations. This model can also be used to compare drug encapsulation efficiencies
Shubhadeep Banerjee et al.
International journal of pharmaceutics, 436(1-2), 786-797 (2012-08-14)
pH-responsive polymers render liposomes pH-sensitive and facilitate the intracellular release of encapsulated payload by fusing with endovascular membranes under mildly acidic conditions found inside cellular endosomes. The present study reports the use of high-molecular weight poly(styrene-co-maleic acid) (SMA), which exhibits
Pan Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(2), 349-354 (2012-07-18)
Ultrasound targeted microbubble destruction (UTMD) was one of the most promising strategies to enhance drug delivery in cancer therapy. Microbubbles (MBs) serve as a vehicle to carry anti-tumor drugs and locally release them when exposed to therapeutic ultrasound, resulting in
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