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O7635

Sigma-Aldrich

Anti-Osteopontin antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-OPN

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About This Item

Numéro MDL:
MFCD02263865
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse

Technique(s)

capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections
neutralization: 1-3 μg/mL
western blot: 0.1-0.2 μg/mL

Numéro d'accès UniProt

P10923

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Spp1(20750)

Description générale

The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.

Immunogène

purified recombinant mouse osteopontin expressed in NSO cells.

Actions biochimiques/physiologiques

Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Remarque sur l'analyse

Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice.
Lee S H, et al.
Oncotarget, 7(52), 87219-87219 (2016)
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.
Ishigamori R, et al.
International Journal of Molecular Sciences, 18(5), 1058-1058 (2017)
Tracking the embryonic stem cell transition from ground state pluripotency.
Kalkan T, et al.
Development, dev-142711 (2017)
Transcriptome analysis of fetal metatarsal long bones by microarray, as a model for endochondral bone formation.
Sugars R V, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1763(10), 1031-1039 (2006)
Mio Yamane et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10778-10800 (2020-07-04)
Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and lose function due to the resultant fibrosis. An abnormal immune
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