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O4375

Sigma-Aldrich

Oxytocin

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

Synonyme(s) :

α-Hypophamine, Oxytocic hormone

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About This Item

Formule empirique (notation de Hill):
C43H66N12O12S2
Numéro CAS:
50-56-6
Poids moléculaire :
1007.19
Numéro Beilstein :
3586108
Numéro MDL:
MFCD00076731
Code UNSPSC :
51111800
ID de substance PubChem :
24897994
Nomenclature NACRES :
NA.32

Source biologique

synthetic

Stérilité

non-sterile

Forme

lyophilized powder

Activité spécifique

~15 IU/mg solid (Prepared from synthetic oxytocin)

Solubilité

water: 10 mg/mL, clear, colorless

Numéro d'accès UniProt

P01178
P30559
P70536

Conditions d'expédition

ambient

Température de stockage

2-8°C

Chaîne SMILES 

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

Clé InChI

XNOPRXBHLZRZKH-DSZYJQQASA-N

Informations sur le gène

human ... OXT(5020) , OXTR(5021)
rat ... Oxtr(25342)

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Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

Description générale

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Application

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.

Actions biochimiques/physiologiques

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).
Stimulates uterine contraction and lactation; increases Na+ excretion; stimulates myometrial GTPase and phospholipase C.

Forme physique

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Mia E Persson et al.
Hormones and behavior, 95, 85-93 (2017-08-03)
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor
Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation
Green KA
Developmental Biology, 299(1), 164-175 (2006)
Margaret M Njoroge et al.
The American journal of tropical medicine and hygiene (2020-12-31)
Intranasal instillation of SE36, a malaria vaccine candidate antigen, in lactating BALB/c female mice resulted in the appearance of the antigen in breast milk as demonstrated by sandwich ELISA and Western blot. Pups born of immunologically naive mice and breastfed
Mary C Peavey et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(11) (2021-03-13)
Uterine contractile dysfunction leads to pregnancy complications such as preterm birth and labor dystocia. In humans, it is hypothesized that progesterone receptor isoform PGR-B promotes a relaxed state of the myometrium, and PGR-A facilitates uterine contraction. This hypothesis was tested
Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children.
Abdulamir HA
Saudi Medical Journal, 37(1), 29-36 (2016)
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