Accéder au contenu
Merck
Toutes les photos(1)

Documents

N6163

Sigma-Aldrich

Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-LNGFR, Anti-Ngfr, Anti-Tnfrsf16, Anti-p75

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme


About This Item

Numéro MDL:
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

human

Technique(s)

western blot: 0.1-0.2 μg/mL

Numéro d'accès UniProt

Température de stockage

−20°C

Informations sur le gène

human ... NGFR(4804)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. Signaling of NGF through NGFR is also implicated in inflammation and allergic reactions. Expression of NGFR has been associated with favourable prognosis and survival in breast and pancreatic cancers
Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes human NGF R.

Immunogène

purified, Sf21-derived recombinant human p75 neurotrophin R extracellular domain.

Application

Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Vous ne trouvez pas le bon produit ?  

Essayez notre Outil de sélection de produits.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Yong Zhang et al.
Oncology reports, 14(1), 161-171 (2005-06-10)
Nerve growth factor (NGF), the prototypic member of the neurotrophin family of growth factors, exerts both stimulatory and inhibitory effects on neuronal and certain non-neuronal tumors, depending on the type of tumor. It has been reported that two types of
Wolfgang Andreas Nockher et al.
The Journal of allergy and clinical immunology, 117(3), 583-589 (2006-03-09)
Understanding the complex pathophysiology of allergic diseases has been a main challenge of clinical and experimental research for many years. It is well known that the allergic inflammation triggers neuronal dysfunction and structural changes in the diseased tissues such as
C D Mills et al.
European journal of pain (London, England), 17(4), 469-479 (2012-08-24)
Injection of nerve growth factor (NGF) produces mechanical and thermal hypersensitivity in rodents and humans. Treatment with sequestering antibodies demonstrates the importance of NGF in various pain states, with efficacy seen in a number of animal pain models and in
Y Indo
Clinical genetics, 82(4), 341-350 (2012-08-14)
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat) and mental retardation. Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and
Hrishikesh M Mehta et al.
Journal of neuroscience research, 90(12), 2259-2271 (2012-08-21)
Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but its

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique