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N6037

Sigma-Aldrich

Neridronate

≥97% (NMR), solid, bone resorption inhibitor

Synonyme(s) :

6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia

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About This Item

Formule empirique (notation de Hill):
C6H17NO7P2
Numéro CAS:
79778-41-9
Poids moléculaire :
277.15
Numéro MDL:
MFCD00866995
Code UNSPSC :
51111800
ID de substance PubChem :
24724553
Nomenclature NACRES :
NA.77

product name

Neridronate, ≥97% (NMR), solid

Description

may contain <1% (w/w) inorganic salts

Niveau de qualité

100

Pureté

≥97% (NMR)

Forme

solid

Couleur

white

Solubilité

H2O: >5 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O

InChI

1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)

Clé InChI

PUUSSSIBPPTKTP-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta, an "orphan disease" characterized by a fragility of the bone enough to be named the "illness of bones of crystal".

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Etidronate disodium hydrate &#8805;97% (NMR), solid

Sigma-Aldrich

P5248

Etidronate disodium hydrate

Alendronate Sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1599

Alendronate Sodium

Zoledronic acid monohydrate &#8805;98% (HPLC)

Sigma-Aldrich

SML0223

Zoledronic acid monohydrate

Zoledronic acid United States Pharmacopeia (USP) Reference Standard

USP

1724827

Zoledronic acid

Massimo Varenna et al.
Rheumatology (Oxford, England), 52(3), 534-542 (2012-12-04)
Complex regional pain syndrome type I (CRPS-I) is a severely disabling pain syndrome for which no definite treatment has been established. The aim of this multi-centre, randomized, double-blind placebo-controlled trial was to test the efficacy of the amino-bisphosphonate neridronate in
Daniela Merlotti et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 26(3), 512-518 (2010-09-04)
Aminobisphosphonates actually represent the most common treatment for Paget disease of bone (PDB). In a previous study we demonstrated that either zoledronic acid (4 mg) or neridronate (200 mg) given as a single intravenous infusion showed a similar short-term efficacy
Gian Luca Forni et al.
British journal of haematology, 158(2), 274-282 (2012-05-11)
Neridronate is a third generation bisphosphonate with established efficacy in metabolic bone disease. In this randomized, open-label study, 118 adults with β-thalassaemia and bone mineral density (BMD) Z scores ≤-2·0 were randomized 1:1-500 mg calcium with 400 international unis (iu)
Filippo Graziani et al.
Journal of clinical periodontology, 36(5), 419-427 (2009-05-08)
To determine if the adjunctive use of intra-muscular neridronate (NE) during non-surgical periodontal treatment (PT) provides, in patients with generalized chronic periodontitis (GCP), adjunctive benefits as compared with PT alone 3 months after the completion of a 3-month NE therapy.
Aino-Liisa Saari et al.
Molecules (Basel, Switzerland), 17(9), 10928-10945 (2012-09-14)
Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is
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