M4145

Minoxidil

≥99% (TLC), powder, androgenetic alopecia drug

• Synonyme(s) : 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
• Formule empirique (notation de Hill): C₉H₁₅N₅O
• Numéro CAS: 38304-91-5
• Poids moléculaire : 209.25
• Numéro CE : 253-874-2
• Numéro MDL: MFCD00063409
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277853
• Nomenclature NACRES : NA.77

Propriétés

• product name: Minoxidil, ≥99% (TLC)
• Pureté: ≥99% (TLC)
• Pf: 272-274 °C (dec.) (lit.)
• Auteur: Johnson & Johnson
• Chaîne SMILES: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• Clé InChI: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• Informations sur le gène: human ... KCNJ1(3758)

Description

Application

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Actions biochimiques/physiologiques

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Caractéristiques et avantages

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H335
• Conseils de prudence: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves