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M2525

Mianserin hydrochloride

5-HT2 serotonin receptor

Synonyme(s) :

1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C18H20N2 · HCl
Numéro CAS:
21535-47-7
Poids moléculaire :
300.83
NACRES:
NA.77
PubChem Substance ID:
24278125
UNSPSC Code:
12352200
EC Number:
244-426-7
MDL number:
MFCD00055072
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Nom du produit

Mianserin hydrochloride,

Quality Segment

200

solubility

H2O: 3.4 mg/mL, ethanol: 5.6 mg/mL

originator

Organon

storage temp.

2-8°C

SMILES string

Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24

InChI

1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H

InChI key

YNPFMWCWRVTGKJ-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)

Application

Mianserin hydrochloride has been used:
  • as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)
  • as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression
  • as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation

Biochem/physiol Actions

Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.
Antidepressant; antagonist/inverse agonist at 5-HT2 serotonin receptors; also blocks the H1 histamine receptor and the α2 adrenoceptor.

Features and Benefits

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Solutions may be stored for several days at 4°C.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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