GW10817F
Anti-TAT antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Anti-Protein Tat, Anti-Transactivating regulatory protein
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
chicken
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Fabricant/nom de marque
Genway 15-288-10817F
Technique(s)
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... tat(155871)
Catégories apparentées
Immunogène
Immunogen Sequence: GI # 9629358, sequence 1-86
Recombinant tat (human immunodeficiency virus 1)
Application
Anti-TAT antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
Actions biochimiques/physiologiques
TAT (Transactivating regulatory protein) is a trans-activator of human immunodeficiency virus-1 (HIV-1) gene expression and is important for virus replication. It binds to the bulge loop RNA element called TAR, but can also associate with cellular transcription factors. Cyclin T binds with TAT and thereby enhances the affinity of TAT-TAR RNA interaction. Protein arginine methyltransferase-6 (PRMT6) is responsible for methylation of TAT and negatively affects the association between TAT and cyclin T. TAT is involved in the activation of nuclear factor κB (NFκB), a master regulator of pro-inflammatory genes. TAT binds with α5β1 and αvβ3 integrins, and causes vascular cell migration and invasion. At the neural plasma membrane, TAT induces formation of a complex involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), N-methyl-d-aspartic acid (NMDA) receptors and neuronal nitric oxide synthase (nNOS). This complex is responsible for apoptosis in neurons and astrocytes, causing neurologic dysfunction in AIDS patients.
Forme physique
Solution in phosphate buffered saline containing 0.02% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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R A Marciniak et al.
The EMBO journal, 10(13), 4189-4196 (1991-12-01)
The Tat protein of HIV-1 trans-activates transcription in vitro in a cell-free extract of HeLa nuclei. Quantitative analysis of the efficiency of elongation revealed that a majority of the elongation complexes generated by the HIV-1 promoter were not highly processive
G Barillari et al.
Blood, 94(2), 663-672 (1999-07-09)
The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during acute infection of T cells by HIV-1 and to promote angiogenesis and Kaposi's sarcoma (KS) development in infected individuals. In this study, we investigated
Eliseo A Eugenin et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(9), 3438-3443 (2007-03-16)
HIV infection of the central nervous system can result in neurologic dysfunction with devastating consequences in AIDS patients. NeuroAIDS is characterized by neuronal injury and loss, yet there is no evidence that HIV can infect neurons. Here we show that
Baode Xie et al.
Journal of virology, 81(8), 4226-4234 (2007-02-03)
Arginine methylation has been shown to regulate signal transduction, protein subcellular localization, gene transcription, and protein-protein interactions that ultimately alter gene expression. Although the role of cellular protein arginine methyltransferases (PRMT) in viral gene expression is largely unknown, we recently
Giuseppe Fiume et al.
Nucleic acids research, 40(8), 3548-3562 (2011-12-22)
Nuclear factor (NF)-κB is a master regulator of pro-inflammatory genes and is upregulated in human immunodeficiency virus 1 (HIV-1) infection. Mechanisms underlying the NF-κB deregulation by HIV-1 are relevant for immune dysfunction in AIDS. We report that in single round
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