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F9911

Sigma-Aldrich

Fibronectin Proteolytic Fragment from human plasma

lyophilized powder, 30 kDa

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About This Item

Code UNSPSC :
12352202
eCl@ss :
42020141
Nomenclature NACRES :
NA.75

Source biologique

human plasma

Niveau de qualité

200

Pureté

>90% (SDS-PAGE)

Forme

lyophilized powder

Poids mol.

30 kDa

Conditionnement

pkg of 0.5 mg

Technique(s)

cell culture | mammalian: suitable

Impuretés

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

Solubilité

water: soluble >0.5 mg/mL, clear to slightly hazy, colorless

Numéro d'accès UniProt

P02751

Conditions d'expédition

ambient

Température de stockage

−20°C

Informations sur le gène

human ... FN1(2335)

Description générale

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Application

Fibronectin proteolytic fragment has been used in solid phase binding assay.

Actions biochimiques/physiologiques

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Attention

The product should be stored at -20°C.

Notes préparatoires

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

En option

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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PloS one, 8(7), e69343-e69343 (2013-08-13)
Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ. Fibronectin (Fn) is an essential component of the ECM, and plays
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The Journal of biological chemistry, 269(22), 15563-15570 (1994-06-03)
The N-terminal 29-kDa fragment of fibronectin (Fn29K) contains five type I "finger" modules. It binds to heparin, fibrin, and bacteria and is involved in fibronectin (Fn) matrix assembly. Binding to Staphylococcus aureus involves a cell wall-associated protein that contains approximately
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E Nègre et al.
The Journal of biological chemistry, 269(35), 22039-22045 (1994-09-02)
A 30-kDa proteolytic fragment from the gelatin/collagen-binding domain of fibronectin is a potent inhibitor of fibronectin binding to Candida albicans, with a molar inhibition constant equal to that of intact fibronectin. Recombinant and proteolytic fragments from the cell-, the fibrin
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Scientific reports, 5, 14449-14449 (2015-09-25)
Bacterial adhesins play a pivotal role in the tight bacteria-host cells attachment to initiate the downstream processes and bacterial infection of hosts. In this study, we identified a novel adhesin, VpadF in V. parahaemolyticus. Deletion of VpadF in V. parahaemolyticus
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