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F9397

Flutamide

Non-steroidal anti-androgen drug

Synonyme(s) :

2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

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A propos de cet article

Formule empirique (notation de Hill) :
C11H11F3N2O3
Numéro CAS:
13311-84-7
Poids moléculaire :
276.21
NACRES:
NA.77
PubChem Substance ID:
24278446
UNSPSC Code:
51111800
EC Number:
236-341-9
MDL number:
MFCD00072009
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Nom du produit

Flutamide,

Quality Segment

100

originator

Schering Plough

SMILES string

CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI

1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)

InChI key

MKXKFYHWDHIYRV-UHFFFAOYSA-N

Gene Information

human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Application

Flutamide has been used to effect of testosterone on Glial cell-derived neurotrophic factor (Gdnf) mRNA production in vitro.[1] It has also been used to study the effects of flutamide on anogenital distance and nipple retention.

Biochem/physiol Actions

Flutamide is a non-steroidal anti-androgen drug. It consists of a nitroaromatic structure. Flutamide is a potent competitor of testosterone and dihydrotestosterone receptors. It is a potent hepatotoxin.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Cet article
H4166N8534SML1626
Flutamide

Sigma-Aldrich

F9397

Flutamide

Hydroxyflutamide ≥98% (HPLC)

Sigma-Aldrich

H4166

Hydroxyflutamide

Nilutamide solid

Sigma-Aldrich

N8534

Nilutamide

TFCA ≥98% (HPLC)

Sigma-Aldrich

SML1626

TFCA

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

originator

Schering Plough

originator

Schering Plough

originator

Sanofi Aventis

originator

-

Gene Information

human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Gene Information

-

Gene Information

human ... AR(367)

Gene Information

-

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2

target_organs

Liver

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Questions

  1. How Can I prepare 1nM solution of flutamide? flutamide dissolves in ethanol? AFTER DISSOLVING flutamide IN ETHANOL , WHATS the storage conditions and useful life?

    1 answer

    1. Flutamide is soluble in ethanol (50 mg/ml) with heat as needed, yielding a clear to hazy, yellow to yellow-green solution. It is also soluble in acetone, ethyl acetate, methanol, chloroform, and ether.

      The molecular weight of flutamide is 276.21, and this value can be used to calculate the amount needed to make a 1nM solution in the desired volume:
      https://www.sigmaaldrich.com/support/calculators-and-apps/mass-molarity-calculator

      Using freshly made solutions whenever possible is always recommended, but storing them at -20°C in non-diluted aliquots should maintain their stability for at least one month.

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