F7876

Folic acid

≥97%

• Synonyme(s) : PteGlu, Pteroyl-L-glutamic acid, Vitamin M
• Formule empirique (notation de Hill) : C₁₉H₁₉N₇O₆
• Numéro CAS: 59-30-3
• Poids moléculaire : 441.40
• NACRES: NA.79
• PubChem Substance ID: 57654192
• eCl@ss: 34058014
• UNSPSC Code: 12352106
• EC Number: 200-419-0
• MDL number: MFCD00079305
• Beilstein/REAXYS Number: 100781

Propriétés

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥97%
• form: powder
• technique(s): HPLC: suitable
• color: faint orange to dark orange-yellow, faint yellow to dark yellow
• mp: >285 °C
• storage temp.: room temp
• SMILES string: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• InChI key: OVBPIULPVIDEAO-LBPRGKRZSA-N

Description

Application

Folic acid has been used:

• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Biochem/physiol Actions

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)