F4759
Bovine Fibronectin
from bovine plasma, powder, suitable for cell culture
Synonyme(s) :
Fibronectin
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About This Item
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352202
eCl@ss :
42020141
Nomenclature NACRES :
NA.75
Produits recommandés
Nom du produit
Fibronectine, powder, BioReagent, suitable for cell culture
Source biologique
bovine plasma
Niveau de qualité
Stérilité
sterile
Gamme de produits
BioReagent
Forme
powder
Poids mol.
~450 kDa
Conditionnement
pkg of 1 mg
pkg of 2 mg
pkg of 5 mg
Concentration
≥1 mg protein/mL
Technique(s)
cell culture | mammalian: suitable
Couverture de surface
1‑5 μg/cm2
Solubilité
H2O: 1 mg/mL at 37 °C (Store reconstituted solution in working aliquots at -20°C or lower.)
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Informations sur le gène
bovine ... FN1(2807940)
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Description générale
Fibronectin is a glycoprotein with multiple domains. It comprises a N-terminal, central binding domain and a heparin-binding domain. Bovine plasma fibronectin has polypeptide chains with disulfide linkage and corresponds to a molecular weight of 220 and 215 kDa.
Fibronectins are adhesive glycoproteins and are found both as cell surface proteins and in plasma. Fibronectin (FN) is a multifunctional glycoprotein, the gene of which is localized to human chromosome 2q34-36. This gene spans 75kb and contains 50 exons. It exists as two major isoforms, one soluble and one insoluble form. The former is present in plasma, whereas the insoluble form resides in tissues and extracellular matrix (ECM) of cartilage. There are around 20 different forms of FN due to alternative splicing of a variable region and two type III exons called Extra Domains A and B.
Application
Fibronectin from bovine plasma is used for the following applications:
- Used for coating the glass coverslips for the culture of decidual stromal cells (DEC)
- Cell movement assays (culture plates were coated with fibronectin)
- Cell spreading and immunofluorescence
- Protein specificity
- Integration of sensor films into microfluidic chips
- Histological and Immunohistochemical (IHC) analyses
- Used in primary cell cultures from patients with lung carcinoma
Actions biochimiques/physiologiques
Fibronectin is a regulator of protein scaffolding. It coordinates cellular processes like platelet functions, wound-healing, adhesion, migration and aggregation.Study shows that human dental pulp (HDP) cells rely on fibronectin (FN) for initial attachment and subsequent spreading. FN may exhibit mitogenic activity, promoting cell proliferation, and also play a role in regulating the differentiation process of pulp cells into odontoblasts. The presence of FN appears to influence the fate and development of HDP cells, specifically in their differentiation into odontoblasts, which are responsible for dentin formation in teeth.
Attention
As supplied, this product should be stored at -20°C and will remain active for at least 2 years.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
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Because of their paternal antigens, the fetus and placenta may be considered an allograft in the maternal host. Local properties of the maternal-fetal interface, the placenta and decidua basalis, are important in preventing maternal immunologic rejection of the fetoplacental allograft.
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