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D8783

Sigma-Aldrich

7-Déaza-2′-déoxyguanosine 5′-triphosphate lithium salt

10 mM in H2O

Synonyme(s) :

−N7-dGTP, 7-Déaza-dGTP

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About This Item

Formule empirique (notation de Hill):
C11H17N4O13P3
Numéro CAS:
101515-08-6
Poids moléculaire :
506.19
Numéro MDL:
MFCD00171614
Code UNSPSC :
41106305
ID de substance PubChem :
24894227
Nomenclature NACRES :
NA.52

Source biologique

Porcine muscle
rabbit muscle

Pureté

≥95% (HPLC)

Forme

liquid

Concentration

10 mM in H2O

Couleur

colorless

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1

InChI

1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)

Clé InChI

DLLXAZJTLIUPAI-UHFFFAOYSA-N

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Catégories apparentées

Application

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt has been used as a lysis agent to evaluate its efficiency on direct cell lysis, RNA stability, and compatibility with downstream reverse transcription quantitative real-time PCR during the analyzes of samples with small numbers of cells.

Actions biochimiques/physiologiques

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-deaza-dGTP) competes with natural substrate dGTP and blocks the telomerase activity. This nucleotide once incorporated into the telomere alters the secondary structure of the telomere making it difficult for telomerase to identify it for further telomere synthesis. This dGTP analog pairs weakly with conventional bases to minimize DNA secondary structures, while being a good substrate for DNA polymerases. 7-deaza-dGTP in combination with dimethyl sulfoxide (DMSO) and betaine enhances the polymerase chain reaction (PCR) amplification of GC-rich DNA sequences.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Tatsuo Hata et al.
The Journal of molecular diagnostics : JMD, 20(1), 46-55 (2017-12-13)
Telomere end-to-end fusions are an important source of chromosomal instability that arise in cells with critically shortened telomeres. We developed a nested real-time quantitative PCR method for telomere fusion detection in pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms (IPMNs), and
Andreas Blecha et al.
Microbial cell factories, 4, 28-28 (2005-10-06)
Native as well as recombinant bacterial cell surface layer (S-layer) protein of Geobacillus (G.) stearothermophilus ATCC 12980 assembles to supramolecular structures with an oblique symmetry. Upon expression in E. coli, S-layer self assembly products are formed in the cytosol. We
Michael Field et al.
International journal of molecular sciences, 20(16) (2019-08-14)
Although fragile X syndrome (FXS) is caused by a hypermethylated full mutation (FM) expansion with ≥200 cytosine-guanine-guanine (CGG) repeats, and a decrease in FMR1 mRNA and its protein (FMRP), incomplete silencing has been associated with more severe autism features in
Russell J Diefenbach et al.
Cancers, 12(8) (2020-08-14)
Detection of melanoma-associated mutations using circulating tumor DNA (ctDNA) from plasma is a potential alternative to using genomic DNA from invasive tissue biopsies. In this study, we developed a custom melanoma next-generation sequencing (NGS) panel which includes 123 amplicons in
Emmanuel F Mongodin et al.
PLoS genetics, 2(12), e214-e214 (2006-12-30)
Arthrobacter sp. strains are among the most frequently isolated, indigenous, aerobic bacterial genera found in soils. Member of the genus are metabolically and ecologically diverse and have the ability to survive in environmentally harsh conditions for extended periods of time.
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