D7693

Dynasore monohydrate

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

• Synonyme(s) : 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate
• Formule empirique (notation de Hill) : C₁₈H₁₄N₂O₄ · xH₂O
• Numéro CAS: 1202867-00-2
• Poids moléculaire : 322.31 (anhydrous basis)
• Numéro MDL: MFCD11045288
• Code UNSPSC : 12352200
• ID de substance PubChem : 329798784
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Dynasore monohydrate,
• Forme: powder
• Niveau de qualité: 100
• Conditions de stockage: protect from light
• Couleur: off-white
• Solubilité: DMSO: ≥10 mg/mL; H₂O: insoluble
• Température de stockage: −20°C
• Chaîne SMILES: O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
• InChI: 1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
• Clé InChI: FKWZHQSDBMSHTN-ZIOFAICLSA-N

Description

Description générale

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Application

Dynasore hydrate has been used:

• for priming fetal mesenchymal stem/stromal cells (fMSC)
• in confocal microscopy
• in wound healing/scratch and tube-formation assay
• to analyse its effects on Coxsackievirus A9 (CAV9) infection
• to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
• in live imaging of cells

Actions biochimiques/physiologiques

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H400
• Conseils de prudence: P273
• Classification des risques: Aquatic Acute 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves