D7128

L-Dihydroorotic acid

≥99%

• Synonyme(s) : 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid, L-Hydroorotic acid, Dihydro-L-orotic acid
• Formule empirique (notation de Hill) : C₅H₆N₂O₄
• Numéro CAS: 5988-19-2
• Poids moléculaire : 158.11
• NACRES: NA.83
• PubChem Substance ID: 24894080
• UNSPSC Code: 12352204
• MDL number: MFCD00085339
• Assay: ≥99%
• Form: powder

Propriétés

• Quality Segment: 200
• assay: ≥99%
• form: powder
• mp: 254-255 °C (dec.) (lit.)
• SMILES string: OC(=O)[C@@H]1CC(=O)NC(=O)N1
• InChI: 1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
• InChI key: UFIVEPVSAGBUSI-REOHCLBHSA-N

Description

Application

L-Dihydroorotic acid has been used as a substrate in dihydroorotate dehydrogenase (DHODH) assay.

Biochem/physiol Actions

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H315,H319,H335
• Mentions de précaution: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Gloves