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D4540

Diméthylsulfoxyde

Name: Diméthylsulfoxyde
Brand: SIGMA

≥99.5% (GC), suitable for plant cell culture

Dimethyl sulfoxide

1 of 2 reviewers received a sample product or took part in a promotion

Synonyme(s) :

DMSO, Sulfoxyde de méthyle

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A propos de cet article

Formule linéaire :

(CH₃)₂SO

Numéro CAS:

67-68-5

Poids moléculaire :

78.13

UNSPSC Code:

12191502

NACRES:

NA.71

PubChem Substance ID:

24893881

EC Number:

200-664-3

Beilstein/REAXYS Number:

506008

MDL number:

MFCD00002089

Assay:

≥99.5% (GC)

Technique(s):

cell culture | plant: suitable, cryopreservation: suitable

Bp:

189 °C (lit.)

Vapor pressure:

0.42 mmHg ( 20 °C)

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Propriétés

Quality Segment

200

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

assay

≥99.5% (GC)

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

technique(s)

cell culture | plant: suitable, cryopreservation: suitable

impurities

<0.1% water (Karl Fischer)

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H₂O: miscible (completely)

density

1.10 g/mL (lit.)

SMILES string

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Description

Application

Le diméthylsulfoxyde a été utilisé :

Dans la préparation de bisphénol A (BPA).
Dans un test de prolifération cellulaire (test au MTT).
Dans un test de chimiosensibilité.
Comme véhicule de contrôle dans toutes les expériences du type étude de l′apoptose.
Dans une étude sur l′éthoxyrésorufine-O-dééthylation (EROD).

Biochem/physiol Actions

Le DMSO (diméthylsulfoxyde), un solvant organique, présente plusieurs propriétés pharmaceutiques : il est notamment analgésique, diurétique, bactériostatique, anti-inflammatoire, vasodilatateur, il pénètre les membranes et il a des effets inhibiteurs sur la cholinestérase. C′est un sous-produit de l′industrie du bois, et il est utilisé comme solvant industriel. Le DMSO sert également d′agent thérapeutique dans le traitement de la cystite interstitielle et de l′arthrite.

Other Notes

Lauréat du prix CiteAb 2024 récompensant les avancées des fournisseurs dans la recherche sur la maladie de Parkinson

Disclaimer

Refroidit facilement et revient doucement à la température de la pièce. Les produits solides peuvent être reliquéfiés par chauffage à la température ambiante sans abîmer le produit.

Comparer avec des articles similaires

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Montrer les différences

1 of 1

Cet article	D2650	D2653	01934
Sigma-Aldrich D4540 Diméthylsulfoxyde	Sigma-Aldrich D2650 Diméthylsulfoxyde	Sigma-Aldrich D2653 Diméthylsulfoxyde	Supelco 01934 Diméthylsulfoxyde
assay ≥99.5% (GC)	assay ≥99.7%	assay ≥99.7%	assay ≥99.9% (GC), ≥99.99995% (metals basis)
Quality Level 200	Quality Level 400	Quality Level 300	Quality Level 100
technique(s) cell culture \| plant: suitable, cryopreservation: suitable	technique(s) cell culture \| hybridoma: suitable, cryopreservation: suitable	technique(s) cell culture \| hybridoma: suitable, cryopreservation: suitable	technique(s) -
solubility H₂O: miscible (completely)	solubility H₂O: miscible (completely)	solubility H₂O: miscible (completely)	solubility H₂O: miscible (completely)
form liquid	form liquid	form liquid	form liquid
mp 16-19 °C (lit.)	mp 16-19 °C (lit.)	mp 16-19 °C (lit.)	mp 16-19 °C

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Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Questions

1–10 of 11 Questions

2 years ago

Can I use this product (suitable for plant cell culture) for cyropreservation of mammalian cells? Does cryopreservation of mammalian cells require sterile-filtered DMSO?

1 answer
1. Technical Support
  
  2 years ago
  
  D4540 is listed as suitable for cryopreservation.
  However, D2650 is already pre-sterile and has documentation with a protocol for cryopreservation of human and animal cell lines.
  See these links:
  https://www.sigmaaldrich.com/product/sigma/d2650
  https://www.sigmaaldrich.com/product/sigma/d2650#product-documentation
  Look for the Product Information Sheet. Also, see this link for more information:
  https://www.sigmaaldrich.com/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-freezing-reagents
  
  Helpful?
3 years ago

Can I autoclave this product?

1 answer
1. Technical Support
  
  3 years ago
  
  DMSO is not autoclavable in neat form. It is highly unlikely that microorganisms would survive in this environment. Should sterilization be necessary a PTFE, Polypropylene, or Nylon filter membrane are recommended for sterile-filtration.
  
  Helpful?
Anonymous

4 years ago

What is the molarity of DMSO?

1 answer
1. Technical Support
  
  4 years ago
  
  DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.
  
  Helpful?
Anonymous

4 years ago

Dimethyl sulfoxide (DMSO) should be a liquid. Why did it arrive as a solid?

1 answer
1. Technical Support
  
  4 years ago
  
  DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.
  
  Helpful?
Anonymous

4 years ago

Does DMSO have any synthetic utility?

1 answer
1. Technical Support
  
  4 years ago
  
  DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.
  
  Helpful?
Anonymous

4 years ago

What is the DMSO dissolved in?

1 answer
1. Technical Support
  
  4 years ago
  
  DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.
  
  Helpful?
Anonymous

4 years ago

Where does DMSO come from?

1 answer
1. Technical Support
  
  4 years ago
  
  DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.
  
  Helpful?
Anonymous

4 years ago

What type of filter is used to sterile-filter Dimethyl sulfoxide (DMSO)?

1 answer
1. Technical Support
  
  4 years ago
  
  DMSO can be sterile-filtered through a 0.2 micron PTFE filter. The sterility testing is per the current US Pharmacopoeia method.
  
  Helpful?
Anonymous

4 years ago

What is the Department of Transportation shipping information for this product?

1 answer
1. Technical Support
  
  4 years ago
  
  Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
  
  Helpful?
Anonymous

4 years ago

What concentration of DMSO do I use in a cell freezing media?

1 answer
1. Technical Support
  
  4 years ago
  
  DMSO is usually used at 1-10%, depending on the cell line. For the cell freezing media that we offer, it is used at 8.7% concentration.
  
  Helpful?