D3168
Duramycin from Streptoverticillium cinnamoneus
≥90.0%
Synonyme(s) :
Duramycin, Lancovutide
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About This Item
Formule empirique (notation de Hill):
C89H125N23O25S3
Numéro CAS:
Poids moléculaire :
2013.28
Numéro MDL:
Code UNSPSC :
51102829
Nomenclature NACRES :
NA.85
Produits recommandés
Niveau de qualité
Essai
≥90.0%
Forme
powder
Solubilité
0.1 M HCl: 10 mg/mL
Spectre d'activité de l'antibiotique
Gram-negative bacteria
Gram-positive bacteria
Mode d’action
protein synthesis | interferes
Température de stockage
2-8°C
Description générale
Chemical structure: tetracycline
Application
Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. It is used to stimulate sodium transport in cultured human colonic epithelia.
Actions biochimiques/physiologiques
Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. It enhances chloride secretion in airway epithelium.
Autres remarques
Keep container tightly closed in a dry and well-ventilated place.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
Soichiro Matsunaga et al.
Langmuir : the ACS journal of surfaces and colloids, 25(14), 8200-8207 (2009-05-13)
We visualized nanometer-scale phospholipid particle fusion by scanning tunneling microscopy (STM) on an alkanethiol-modified gold substrate, induced by duramycin, a tetracyclic antibiotic peptide with 19 amino residues. Ultrasonic homogenization generated a suspension mainly consisting of minimal lipid particles (MLP) from
Jason H Stafford et al.
Neoplasia (New York, N.Y.), 13(4), 299-308 (2011-04-08)
We have previously shown that oxidative stress within the tumor microenvironment causes phosphatidylserine (PS) to redistribute from the inner to the outer membrane leaflet of the endothelial cells (EC) creating a highly specific marker for the tumor vasculature. Because the
Ming Zhao et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(8), 1345-1352 (2008-07-18)
With only 19 amino acids, duramycin is the smallest known polypeptide that has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. As an abundant binding target, PtdE is a
Ilka Steiner et al.
Naunyn-Schmiedeberg's archives of pharmacology, 378(3), 323-333 (2008-05-27)
Duramycin (Moli1901) is being developed for the treatment of reduced mucociliary clearance in cystic fibrosis. This study was conducted to estimate lung residence time and systemic exposure and to assess whether duramycin causes an inflammatory response. Six volunteers were administered
M M Cloutier et al.
Membrane biochemistry, 10(2), 107-118 (1993-04-01)
Duramycin increases short-circuit current (Isc) and net Cl- secretion in tracheal epithelium. We measured the intracellular free calcium ([Ca2+]i) response to duramycin using Indo-1 and bovine and canine tracheal cell suspensions, and the effect of an intracellular calcium chelator, BAPTA
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