D2625

Dansyl chloride

BioReagent, suitable for amino acid labeling, powder and chunks, ≥99% (HPLC)

• Synonyme(s) : 5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl
• Formule empirique (notation de Hill) : C₁₂H₁₂ClNO₂S
• Numéro CAS: 605-65-2
• Poids moléculaire : 269.75
• UNSPSC Code: 12352101
• NACRES: NA.26
• PubChem Substance ID: 24893700
• EC Number: 210-092-6
• Beilstein/REAXYS Number: 2217205
• MDL number: MFCD00003985

Propriétés

• product line: BioReagent
• Quality Segment: 200
• assay: ≥99% (HPLC)
• form: powder and chunks
• color: yellow to yellow-orange
• mp: 72-74 °C (lit.)
• solubility: acetone: 20 mg/mL
• suitability: suitable for amino acid labeling
• storage temp.: 2-8°C
• SMILES string: CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O
• InChI: 1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
• InChI key: XPDXVDYUQZHFPV-UHFFFAOYSA-N

Description

Application

Dansyl chloride has been used:

• as a fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase high performance liquid chromatography (HPLC)
• in the derivatization of plasma samples
• in the quantification of immobilized alkaline phosphatase

A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

Biochem/physiol Actions

Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.

Informations sur la sécurité

• pictograms: GHS05
• signalword: Danger
• hcodes: H290,H314
• pcodes: P234 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Classe de stockage: 8A - Combustible corrosive hazardous materials
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges