C6492

Ciproxifan hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride
• Formule empirique (notation de Hill) : C₁₆H₁₈N₂O₂ · HCl
• Numéro CAS: 1049741-81-2
• Poids moléculaire : 306.79
• NACRES: NA.77
• PubChem Substance ID: 24724449
• UNSPSC Code: 12352200
• MDL number: MFCD08705321
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, under inert gas

Propriétés

• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, under inert gas
• color: off-white
• solubility: DMSO: 30 mg/mL, water, high purity: 30 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
• InChI: 1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H
• InChI key: PWAPSKMHZQQTRJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Ciproxifan belongs to a novel chemical series of histamine H₃-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H₃ autoreceptor controlling ³H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H₃ receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H₃ receptor labeled with ¹²⁵I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H₃-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

H₃ histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves