C1057
Butyrylcholinesterase from equine serum
lyophilized powder, ≥900 units/mg protein
Synonyme(s) :
Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
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About This Item
Produits recommandés
Forme
lyophilized powder
Activité spécifique
≥900 units/mg protein
Poids mol.
tetramer 440 kDa
Composition
Protein, ≥10%
Solubilité
H2O: soluble 10 mg/mL
Application(s)
diagnostic assay manufacturing
Température de stockage
−20°C
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Application
Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents. Cholinesterases have also been investigated for their role in Alzheimer′s disease.
Actions biochimiques/physiologiques
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate.
Définition de l'unité
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
Forme physique
Highly purified; contains buffer salts
Remarque sur l'analyse
Protein determined by biuret
Inhibiteur
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Resp. Sens. 1
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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