C0400

Carmustine

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

• Synonyme(s) : 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU
• Formule empirique (notation de Hill) : C₅H₉Cl₂N₃O₂
• Numéro CAS: 154-93-8
• Poids moléculaire : 214.05
• NACRES: NA.77
• PubChem Substance ID: 24278289
• UNSPSC Code: 12352200
• EC Number: 205-838-2
• MDL number: MFCD00057706
• Assay: ≥98%
• Form: (Oily liquid to amorphous solid)

Propriétés

• Nom du produit: Carmustine, ≥98%
• Quality Segment: 200
• assay: ≥98%
• form: (Oily liquid to amorphous solid)
• mp: 30 °C (lit.)
• solubility: ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow
• originator: Bristol-Myers Squibb
• storage temp.: −20°C
• SMILES string: ClCCNC(=O)N(CCCl)N=O
• InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
• InChI key: DLGOEMSEDOSKAD-UHFFFAOYSA-N
• Gene Information: human ... GSR(2936)

Description

General description

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.

Application

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector. It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.

Biochem/physiol Actions

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks. Effective against glioma and other solid tumors.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mot-clé: Danger
• Codes de danger: H300,H350,H360
• Mentions de précaution: P201 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges