B6542

Bréfeldine A

≥99% (HPLC and TLC), BioXtra, Molecular Biology

• Synonyme(s) : γλ-Lactone de l’acide γ,4-Dihydroxy-2-(6-hydroxy-1-heptényl)-4-cyclopentanecrotonique, Ascotoxine, BFA, Cyanéine, Décumbine
• Formule empirique (notation de Hill) : C₁₆H₂₄O₄
• Numéro CAS: 20350-15-6
• Poids moléculaire : 280.36
• UNSPSC Code: 12352200
• NACRES: NA.52
• PubChem Substance ID: 24891917
• MDL number: MFCD12913297
• Beilstein/REAXYS Number: 25191
• Assay: ≥99% (HPLC and TLC)
• Form: powder

Propriétés

• biological source: Penicillium brefeldianum
• Quality Segment: 300
• grade: Molecular Biology
• product line: BioXtra
• assay: ≥99% (HPLC and TLC)
• form: powder
• mol wt: 280.36
• solubility: DMSO: 10 mg/mL (Store stock solutions at -20 °C)
• antibiotic activity spectrum: neoplastics
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1
• InChI: 1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
• InChI key: KQNZDYYTLMIZCT-KQPMLPITSA-N

Description

General description

Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.

Chemical structure: macrolide

Application

Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport

Biochem/physiol Actions

La bréfeldine A (BFA) est un métabolite fongique qui perturbe la structure et la fonction de l′appareil de Golgi. La BFA est un activateur du cycle de la sphingomyéline. Une apoptose médiée par la bréfeldine A a été observée dans des cellules tumorales humaines.

Perturbe la structure et la fonction de l′appareil de Golgi ; activateur du cycle de la sphingomyéline.

Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.

Informations sur la sécurité

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves