A8937

Adenosine 5′-triphosphate dipotassium salt hydrate

from microbial, ≥92% (HPLC)

• Synonyme(s) : ATP, 5′-ATP-K₂
• Formule empirique (notation de Hill): C₁₀H₁₄K₂N₅O₁₃P₃ · xH₂O
• Numéro CAS: 42373-41-1
• Poids moléculaire : 583.36 (anhydrous basis)
• Numéro MDL: MFCD00084672
• Code UNSPSC : 41106305
• eCl@ss : 32160414
• ID de substance PubChem : 24891383
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: microbial
• Niveau de qualité: 200
• Essai: ≥92% (HPLC)
• Forme: powder
• Solubilité: H₂O: 50 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: [K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
• Clé InChI: YFPSRAQDZYNYPX-IDIVVRGQSA-L

Description

Description générale

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.

Application

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:

• in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
• as a component of energy solution for calibrating crude cell extract
• to test its dependency with PK11195 in mediating autophagy

Actions biochimiques/physiologiques

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems.

Attention

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves