A8727

Antalarmin hydrochloride

≥98% (HPLC), solid, CRF1 antagonist

• Synonyme(s) : N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
• Formule empirique (notation de Hill) : C₂₄H₃₄N₄·HCl
• Numéro CAS: 220953-69-5
• Poids moléculaire : 415.01
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724401
• NACRES: NA.77
• MDL number: MFCD05664721
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Propriétés

• Nom du produit: Antalarmin hydrochloride, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
• InChI: 1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
• InChI key: CGDGXEDXEXACKQ-UHFFFAOYSA-N

Description

Application

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Antalarmin hydrochloride has been used:

• to study its effect on stress-induced tryptophan hydroxylase 2 activity
• to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation
• to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression

Biochem/physiol Actions

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

Features and Benefits

This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)