A7229

PUGNAc

≥95% (HPLC)

• Synonyme(s) : O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
• Formule empirique (notation de Hill) : C₁₅H₁₉N₃O₇
• Numéro CAS: 132489-69-1
• Poids moléculaire : 353.33
• UNSPSC Code: 12352204
• NACRES: NA.26
• PubChem Substance ID: 329770921
• MDL number: MFCD00145022
• Beilstein/REAXYS Number: 4274031
• Assay: ≥95% (HPLC)
• Form: crystals

Propriétés

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: crystals
• storage temp.: −20°C
• SMILES string: CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O\C1=N/OC(=O)Nc2ccccc2
• InChI: 1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-/t10-,11-,12-,13-/m1/s1
• InChI key: PBLNJFVQMUMOJY-JXZOILRNSA-N

Description

Application

PUGNAc has been used as an inhibitor of O-GlcNAc-β-N-acetylglucosaminidase.

O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) has been used to evaluate the effects of silibinin on O-GlcNAc levels of glycoproteins in Adult Retinal Pigment Epithelial-19 (ARPE-19) cells. It has also been used as a component of the HEPES lysis buffer for rat brain samples.

Biochem/physiol Actions

PUGNAc is an in vitro and in vivo inhibitor of peptide O-GlcNAc-β-N-acetylglucosaminidase, the enzyme which removes O-linked N-acetylglucosamine (O-GlcNAc) from O-linked glycosylated proteins.

O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) induces insulin resistance in 3T3-L1 adipocytes by reducing insulin-prompting phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3β (GSK3β).

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Gloves, type N95 (US)