A7111

Acepromazine maleate

≥98% (HPLC), ABCG2 inhibitor, powder

• Synonyme(s) : Acetopromazine maleate salt, 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt, Acepromazine maleate salt
• Formule empirique (notation de Hill) : C₁₉H₂₂N₂OS · C₄H₄O₄
• Numéro CAS: 3598-37-6
• Poids moléculaire : 442.53
• NACRES: NA.77
• PubChem Substance ID: 329770915
• UNSPSC Code: 12352200
• EC Number: 222-748-9
• MDL number: MFCD00082473
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Propriétés

• Nom du produit: Acepromazine maleate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: yellow
• solubility: H₂O: >10 mg/mL
• storage temp.: room temp
• SMILES string: OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O
• InChI: 1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: FQRHOOHLUYHMGG-BTJKTKAUSA-N

Description

Application

Acepromazine maleate has been used:

• as a component of anesthesia cocktail to test its effects on behavioral changes in rats
• as a component of anesthesia cocktail to study its effects on lung resistance of rats
• as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells

Biochem/physiol Actions

Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.

Atypical neuroleptic.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mot-clé: Danger
• Codes de danger: H301,H336
• Mentions de précaution: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 3
• Organes cibles: Central nervous system
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable