A4377

S-(5′-Adenosyl)-L-methionine iodide

≥80% (spectrophotometric assay), suitable for cell culture

• Synonyme(s) : AdoMet, SAM
• Formule empirique (notation de Hill) : C₁₅H₂₃IN₆O₅S
• Numéro CAS: 3493-13-8
• Poids moléculaire : 526.35
• NACRES: NA.26
• PubChem Substance ID: 24890852
• UNSPSC Code: 12352209
• EC Number: 222-486-5
• MDL number: MFCD00043192
• Beilstein/REAXYS Number: 4120787

Propriétés

• Nom du produit: S-(5′-Adenosyl)-L-methionine iodide, ≥80% (HPLC), ≥80% (spectrophotometric assay)
• Quality Segment: 200
• assay: ≥80% (HPLC), ≥80% (spectrophotometric assay)
• form: powder
• technique(s): cell culture | mammalian: suitable
• color: white to off-white
• solubility: H₂O: 100 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [I-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C15H22N6O5S.HI/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7-,8+,10+,11+,14+,27?;/m0./s1
• InChI key: XQMWYLXPEGFCFT-XKGORWRGSA-N

Description

Application

S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Analysis Note

Purity based on UV and HPLC.

Disclaimer

This material is very unstable at room temperature.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type N95 (US)