A3537

5-Aminosalicylic acid

powder, ≥99%

• Synonyme(s) : 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine
• Formule linéaire : H₂NC₆H₃-2-(OH)CO₂H
• Numéro CAS: 89-57-6
• Poids moléculaire : 153.14
• Beilstein: 2090421
• Numéro CE : 201-919-1
• Numéro MDL: MFCD00007877
• Code UNSPSC : 12352204
• ID de substance PubChem : 24890780
• Nomenclature NACRES : NA.83

Propriétés

• Nom du produit: 5-Aminosalicylic acid, ≥99%
• Essai: ≥99%
• Forme: powder
• Couleur: off-white to gray
• Pf: 275-280 °C (dec.) (lit.)
• Solubilité: 1 M HCl: 50 mg/mL, clear, yellow to brown
• Température de stockage: 2-8°C
• Chaîne SMILES: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• Clé InChI: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Informations sur le gène: human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

Description

Application

5-Aminosalicylic acid (5-ASA) has been used:

• to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin
• in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover
• to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Actions biochimiques/physiologiques

5-Aminosalicylic acid (5-ASA) is a first-line medicine, used to treat inflammatory bowel diseases like ulcerative colitis (UC). It has a high-efficiency rate in maintenance and induction of remission. 5-ASA is an active component of sulfasalazine and also consists of the carbohydrate polymer, inulin. It might exhibit anti-oxidant activity to lessen tissue injury. 5-ASA is vital for the prevention of T cell activation and proliferation. It negatively regulates cyclooxygenase and lipoxygenase pathways and lowers the formation of prostaglandins and leukotrienes. 5-ASA stimulates the membranous expression of E-cadherin and boosts intercellular adhesion.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H317,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): No data available
• Point d'éclair (°C): No data available
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves