A3085

5-(N-Ethyl-N-isopropyl)amiloride

≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor

• Synonyme(s) : EIPA
• Formule empirique (notation de Hill) : C₁₁H₁₈ClN₇O
• Numéro CAS: 1154-25-2
• Poids moléculaire : 299.76
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278223
• NACRES: NA.77
• MDL number: MFCD00151710
• Assay: ≥98% (TLC)
• Form: powder

Propriétés

• Nom du produit: 5-(N-Ethyl-N-isopropyl)amiloride,
• biological source: synthetic
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• mp: 202-205 °C (lit.)
• solubility: methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
• storage temp.: 2-8°C
• SMILES string: CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
• InChI: 1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
• InChI key: QDERNBXNXJCIQK-UHFFFAOYSA-N
• Gene Information: human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) ; mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) ; rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)

Description

Application

5-(N-Ethyl-N-isopropyl)amiloride has been used:

• as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
• in Pluronic F-127 stock solution for Drosophila larval live-imaging
• in choline chloride solution as an experimental perfusate, to study the effect of Na⁺/H⁺ inhibition on jejunal loop perfusion in vivo

Biochem/physiol Actions

Selective blocker of Na⁺/H⁺ antiport

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves