A0752

Adenosine 5′-diphosphoribose sodium salt

≥93%

• Synonyme(s) : ADPR, ADP-Ribose
• Formule empirique (notation de Hill): C₁₅H₂₃N₅O₁₄P₂
• Numéro CAS: 68414-18-6
• Poids moléculaire : 559.32
• Numéro MDL: MFCD00136017
• Code UNSPSC : 41106305
• ID de substance PubChem : 24890449
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: yeast (candida utilis)
• Pureté: ≥93%
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: [Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O
• InChI: 1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;
• Clé InChI: NWPVXDZLQTURKI-UHFFFAOYSA-N

Description

Application

5′-Deoxy-5′-(methylthio)adenosine has been used:

• to give a range of nicotinamide adenine dinucleotide (NADH)
• oxidation rates for the respiratory complex (CI/CIII/CIV)
• CI/alternative(AOX) pathway
• to measure poly(ADP-ribose) glycohydrolaseactivity
• poly(ADP-ribose) (PAR) binding competition assay
• oxidase (AOX) pathway
• to measure poly(ADP-ribose) glycohydrolase activity
• poly(ADP-ribose) (PAR) binding competition assay

Actions biochimiques/physiologiques

Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na⁺, Ca2⁺, and K⁺ cation channel.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves