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479M-9

Sigma-Aldrich

MDM2 (IF2) Mouse Monoclonal Antibody

Synonyme(s) :

Mouse double minute protein 2

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About This Item

Code UNSPSC :
12352203

Source biologique

mouse

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

IF2, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (479M-94)
vial of 0.1 mL concentrate Research Use Only (479M-94-RUO)
vial of 0.5 mL concentrate (479M-95)
vial of 1.0 mL concentrate (479M-96)
vial of 1.0 mL concentrate Research Use Only (479M-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (479M-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (479M-97)
vial of 7.0 mL pre-dilute ready-to-use (479M-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (479M-98-RUO)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

Isotype

IgG

Contrôle

dedifferentiated liposarcoma, well-differentiated liposarcoma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Catégories apparentées

Description générale

Mouse double minute protein 2 (MDM2) is a gene encoded on the 12q13-14 chromosomal sequence.1-5 It encodes for a 483 amino acid residue protein which binds to the amino-terminal transcription region of p53.2,5 MDM2 has been shown to negatively regulate the tumor-suppressor activity of p53 by three mechanisms: Blocking p53 transcription, binding to p53 causing it to be exported from the nucleus, and accelerating the destruction of p53.1 MDM2 up-regulation has been shown in liposarcoma while being absent in lipoma.2,4 Therefore, anti-MDM2 has been demonstrated to be a potentially useful tool in distinguishing well-differentiated liposarcoma (atypical lipomatous tumor) from lipoma, with the neoplastic cells positive in the former lesion and negative in lipoma.2,4

Qualité

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Matthieu Bui Nguyen Binh et al.
American journal of clinical pathology, 125(5), 693-697 (2006-05-19)
MDM2 and CDK4 immunostaining can be useful adjuncts in diagnosing liposarcoma among soft tissue neoplasms. We examined the reproducibility of MDM2 and CDK4 staining between 2 laboratories and between tissue microarrays and whole tissue sections. Sixty-two soft tissue tumors were
J Momand et al.
Nucleic acids research, 26(15), 3453-3459 (1998-07-22)
The p53 tumor suppressor gene is inactivated in human tumors by several distinct mechanisms. The best characterized inactivation mechanisms are: (i) gene mutation; (ii) p53 protein association with viral proteins; (iii) p53 protein association with the MDM2 cellular oncoprotein. The
A Arici et al.
Indian journal of cancer, 50(3), 164-169 (2013-09-26)
Liposarcomas are among the most common soft tissue sarcomas in adulthood. The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of
Stanislava Uhrinova et al.
Journal of molecular biology, 350(3), 587-598 (2005-06-15)
Critical to the inhibitory action of the oncogene product, MDM2, on the tumour suppressor, p53, is association of the N-terminal domain of MDM2 (MDM2N) with the transactivation domain of p53. The structure of MDM2N was previously solved with a p53-derived
Patrick L Ware et al.
American journal of clinical pathology, 141(3), 334-341 (2014-02-12)
MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. Forty-six cases of liposarcoma in various sites
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