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Principaux documents

465R-1

Sigma-Aldrich

TROP2 (EP431) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

Trophoblast Antigen 2

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP431, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (465R-14)
vial of 0.1 mL concentrate Research Use Only (465R-14-RUO)
vial of 0.5 mL concentrate (465R-15)
vial of 1.0 mL concentrate (465R-16)
vial of 1.0 mL concentrate Research Use Only (465R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (465R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (465R-17)
vial of 7.0 mL pre-dilute ready-to-use (465R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (465R-18-RUO)

Fabricant/nom de marque

Cell Marque®

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Isotype

IgG

Contrôle

papillary carcinoma of thyroid

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic, membranous

Informations sur le gène

human ... TACSTD2(4070)

Catégories apparentées

Description générale

Trophoblast antigen 2 (TROP2) is a transmembrane glycoprotein that transduces intracellular calcium signals. The overexpression of TROP2 has been linked to tumor progression due to its involvement in the regulation of multiple vital cell processes including migration, proliferation, and invasion. TROP2 exhibits strong, diffuse staining in papillary thyroid carcinoma, while staining in other thyroid lesions, such as follicular thyroid adenomas and carcinomas, is limited to rare, focal, or scattered cells. An increase in TROP2 expression has also been observed in colorectal carcinomas and ovarian serous carcinomas compared to non-neoplastic ovary and colon.

Qualité


IVD
IVD
IVD
RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: [email protected]

Informations légales

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

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Certificats d'analyse (COA)

Lot/Batch Number
0000406949
0000377573
0000366879
0000357629
0000354673

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Lara P Stepan et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 59(7), 701-710 (2011-05-10)
Trop2 is a cell-surface glycoprotein reported to be overexpressed in various types of adenocarcinomas with minimal expression in normal tissues. Recent findings that Trop2 expression correlates with tumor aggressiveness have increased interest in Trop2 as a potential target for cancer
Andrey Bychkov et al.
Pathology, 48(5), 425-433 (2016-06-18)
We aimed to evaluate the diagnostic utility of the novel immunohistochemical marker TROP-2 on thyroid specimens (226 tumours and 207 controls). Whole slide immunohistochemistry was performed and scored by automated digital image analysis. Non-neoplastic thyroid, follicular adenomas, follicular carcinomas, and
Haiyan Liu et al.
Applied immunohistochemistry & molecular morphology : AIMM, 25(8), 525-533 (2016-02-11)
Human trophoblast cell-surface marker (TROP-2) has been reported to be overexpressed in various human carcinomas (CAs) and suggested to be a prognostic marker for some CAs. The diagnostic utility of TROP-2 in CAs has not been explored. Immunohistochemical evaluation of
E Ripani et al.
International journal of cancer, 76(5), 671-676 (1998-06-04)
Trop-2/EGP-1/GA733-1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Thus, we investigated whether Trop-2 might be a functional
Bin Wu et al.
Experimental and therapeutic medicine, 14(3), 1947-1952 (2017-10-01)
Human trophoblastic cell-surface marker, tumor-associated calcium signal transducer 2 (TROP2), is a newly identified marker that has a vital role in the proliferation and invasion of various tumors. However, its specific function in ovarian cancer has not been researched. The

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