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315R-1

Sigma-Aldrich

PD-1 (EP239) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

CD279, PD1, PDCD1, SLEB2, hPH-1, hSLE1, programmed cell death 1, programmed cell death protein 1, protein PD-1, systemic lupus erythematosus suseptibilitl 2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP239, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (315R-14)
vial of 0.1 mL concentrate Research Use Only (315R-14-RUO)
vial of 0.5 mL concentrate (315R-15)
vial of 1.0 mL concentrate (315R-16)
vial of 1.0 mL concentrate Research Use Only (315R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (315R-17-RUO)
vial of 1.0 mL predilute ready-to-use (315R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (315R-18-RUO)
vial of 7.0 mL predilute ready-to-use (315R-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

Isotype

IgG

Contrôle

lymph node, tonsil

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic, membranous

Informations sur le gène

human ... PDCD1(5133)

Catégories apparentées

Description générale

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

Qualité

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Liaison

PD-1 Positive Control Slides, Product No. 315S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome.
Kobayashi M, Kawano S, Hatachi S, et al.
The Journal of Rheumatology, 32(11), 2156-2163 (2005)
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Hamanishi J, Mandai M, Iwasaki M, et al.
Proceedings of the National Academy of Sciences of the USA, 104(9), 3360-3365 (2007)
David M Dorfman et al.
The American journal of surgical pathology, 30(7), 802-810 (2006-07-05)
Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family, is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of angioimmunoblastic
Anne Isine Bolstad et al.
Arthritis and rheumatism, 48(1), 174-185 (2003-01-16)
To assess salivary gland tissues obtained from patients with primary Sjögren's syndrome (SS) for the gene expression profile of the candidate genes TNFRSF6 (Fas), TNFSF6 (FasL), SSA1 (Ro52 alpha and the splice variant Ro52 beta), SSB (La), CTLA4, PDCD1 (PD-1)
Yoshiko Iwai et al.
Immunology letters, 83(3), 215-220 (2002-07-04)
PD-1 is an immunoinhibitory receptor, which belongs structurally to the CD28 family. PD-1-deficient mice show breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. We previously described expression of PD-1 on activated T and B lymphocytes and myeloid cells. However
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