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163M-1

Sigma-Aldrich

CD163 (MRQ-26) Mouse Monoclonal Antibody

clone MRQ-26, unconjugated, Cell Marque™

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

MRQ-26, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (163M-14)
vial of 0.5 mL concentrate (163M-15)
bottle of 1.0 mL predilute (163M-17)
vial of 1.0 mL concentrate (163M-16)
bottle of 7.0 mL predilute (163M-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

Isotype

IgG1

Contrôle

inflamed tissue

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic, membranous

Informations sur le gène

human ... CD163(9332)

Description générale

CD163, also known as scavenger receptor cysteine-rich type 1 protein M130, is an acute phase-regulated and signal-inducing transmembrane protein found exclusively on cells of monocytic origin. CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes. Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin. Anti-CD163labels cells of monocytic-macrophage lineage, with expression in the bone marrow and histiocytic neoplasms.

Qualité


IVD
IVD
IVD
RUO

Liaison

CD163 Positive Control Slides, Product No. 163S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Anders Etzerodt et al.
Antioxidants & redox signaling, 18(17), 2352-2363 (2012-08-21)
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages
P Högger et al.
Journal of immunology (Baltimore, Md. : 1950), 161(4), 1883-1890 (1998-08-26)
The RM3/1 Ag is a membrane glycoprotein restricted to human monocytes and macrophages that evolve in the late phase of inflammation. Peptide sequence analysis of the RM3/1 protein revealed similarity to CD163, a member of the scavenger receptor cysteine-rich family.
E Backé et al.
Journal of clinical pathology, 44(11), 936-945 (1991-11-01)
A new monoclonal antibody Ber-MAC3 is reported. It recognises a formol sensitive epitope of a not yet clustered monocyte/macrophage specific 140 kilodalton glycoprotein that is expressed on the cell surface and in the cytoplasm. In 30 cases of acute and
Atsushi Hiraoka et al.
Pathology, research and practice, 201(5), 379-384 (2005-07-29)
CD163 is a marker of activated macrophages, and increased levels of soluble CD163 have been detected in sera obtained from patients with hepatitis. The aim of this study was to detect the expression of CD163 in the liver from patients
Haonan Lu et al.
Cell reports. Medicine, 4(7), 101092-101092 (2023-06-23)
Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm
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