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Key Documents

123R-1

Sigma-Aldrich

CD23 (SP23) Rabbit Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

SP23, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (123R-14)
vial of 0.5 mL concentrate (123R-15)
bottle of 1.0 mL predilute (123R-17)
vial of 1.0 mL concentrate (123R-16)
bottle of 7.0 mL predilute (123R-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotype

IgG1

Contrôle

tonsil

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

membranous

Informations sur le gène

human ... FCER2(2208)

Catégories apparentées

Description générale

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.1 Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/ macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and B-cell Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL/SLL).

Liaison

CD23 Positive Control Slides, Product No. 123S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

D C Rowlands et al.
The Journal of pathology, 160(3), 239-243 (1990-03-01)
The leukocyte antigen CD23 is expressed during B-cell development, and functions as an IgE receptor and a lymphocyte growth factor. We studied the expression of CD23 in paraffin sections of lymphoid tissue using the monoclonal antibody BU38. Fifteen cases of
Francesco DiRaimondo et al.
Cancer, 94(6), 1721-1730 (2002-03-29)
CD23 antigen is a cell surface protein considered important in the differentiation of chronic lymphocytic leukemia (CLL) from other lymphoid leukemias. To better clarify CD23 role as a diagnostic tool, the authors retrospectively evaluated clinical and laboratory features of 372
S Raghoebier et al.
Blood, 78(10), 2680-2685 (1991-11-15)
Large cell lymphomas (LCLs) are heterogeneous in morphology, clinical presentation, and behavior. We studied 52 de novo LCLs of B-cell type for rearrangements of the bcl-2 and c-myc oncogenes by Southern blot analysis and related these data to the primary

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