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D2950000

Disulfiram

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Tetraethylthiuram disulfide, Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Formule linéaire :
(C2H5)2NCSS2CSN(C2H5)2
Numéro CAS:
97-77-8
Poids moléculaire :
296.54
Numéro Beilstein :
1712560
Numéro CE :
202-607-8
Numéro MDL:
MFCD00009048
Code UNSPSC :
41116107
ID de substance PubChem :
329798762
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

disulfiram

Fabricant/nom de marque

EDQM

Pf

69-71 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

Clé InChI

AUZONCFQVSMFAP-UHFFFAOYSA-N

Informations sur le gène

human ... ALDH2(217)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Alcohol dehydrogenase inhibitor.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Health hazardExclamation markEnvironment
GHS08,GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H317,H373,H410

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Pier Paolo Pani et al.
The Cochrane database of systematic reviews, (1)(1), CD007024-CD007024 (2010-01-22)
Cocaine dependence is a disorder for which no pharmacological treatment of proven efficacy exists, advances in the neurobiology could guide future medication development. To evaluate the efficacy and the acceptability of disulfiram for cocaine dependence. We searched: PubMed, EMBASE, CINAHL
Boris Cvek et al.
Drug discovery today, 13(15-16), 716-722 (2008-06-27)
The major approach to the development of anticancer drugs involves searching for new compounds, efficient against malignancies, which are not, as yet, used clinically. This strategy is time-consuming and expensive. Recent studies have disclosed a surprising, but mechanistically consistent, anticancer
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Alcoholism, clinical and experimental research, 35(10), 1749-1758 (2011-05-28)
Alcohol use disorders (AUD) involving hazardous, harmful, and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of disulfiram in the treatment of patients with AUD. The
P Liu et al.
British journal of cancer, 109(7), 1876-1885 (2013-09-07)
Triple-negative breast cancer (TNBC) has significantly worse prognosis. Acquired chemoresistance remains the major cause of therapeutic failure of TNBC. In clinic, the relapsed TNBC is commonly pan-resistant to various drugs with completely different resistant mechanisms. Investigation of the mechanisms and
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Toxicology, 315, 55-64 (2013-08-15)
Several studies have reported that hydrogen peroxide (H2O2) is related to the toxicity of amyloid β (Aβ), and that the accumulation of Aβ in the lenses of humans causes lens opacification. In this study, we investigate the accumulation of Aβ1-42
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