MAB5264
Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211
clone 8211, Chemicon®, from mouse
Synonyme(s) :
NGF-Receptor p75, Low Affinity NGF Receptor, NGFR
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
8211, monoclonal
Espèces réactives
human
Fabricant/nom de marque
Chemicon®
Technique(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... NTF3(4908)
Description générale
The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.
Spécificité
Reacts with NGF-receptors in human system.
Immunogène
Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).
Application
Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.
Immunohistochemistry: 5-10 μg/mL
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
Description de la cible
75 kDa
Liaison
Replaces: 04-1111
Forme physique
Format: Purified
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Gaetana Minnone et al.
RMD open, 3(2), e000441-e000441 (2017-09-29)
To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. Real-time PCR, western blot and ELISA were performed to evaluate NGF, proNGF, their receptor and cytokine expression in synovial tissue
Daisuke Ito et al.
PloS one, 14(3), e0213252-e0213252 (2019-03-07)
Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs with naturally-occurring spinal cord injury; safety trials
Mary-Louise Rogers et al.
Journal of neuroimmunology, 226(1-2), 93-103 (2010-06-16)
The common neurotrophin receptor P75NTR, its co-receptor sortilin and ligand proNGF, have not previously been investigated in Natural Killer (NK) cell function. We found freshly isolated NK cells express sortilin but not significant amounts of P75NTR unless exposed to interleukin-12
Darren Carwardine et al.
PloS one, 12(12), e0188967-e0188967 (2017-12-12)
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix
Darren Carwardine et al.
Journal of the neurological sciences, 367, 311-318 (2016-07-18)
A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an
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