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MAB5264

Sigma-Aldrich

Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

clone 8211, Chemicon®, from mouse

Synonyme(s) :

NGF-Receptor p75, Low Affinity NGF Receptor, NGFR

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

8211, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NTF3(4908)

Description générale

The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.

Spécificité

Reacts with NGF-receptors in human system.

Immunogène

Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).

Application

Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.
Immunohistochemistry: 5-10 μg/mL

Immunocytochemistry: 5-10 μg/mL

Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf

Western Blot: 1ug/mL

Immunoabsorptive purification of NGF-receptors

Optimal working dilutions must be determined by end user.

Description de la cible

75 kDa

Liaison

Replaces: 04-1111

Forme physique

Format: Purified

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Gaetana Minnone et al.
RMD open, 3(2), e000441-e000441 (2017-09-29)
To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. Real-time PCR, western blot and ELISA were performed to evaluate NGF, proNGF, their receptor and cytokine expression in synovial tissue
Daisuke Ito et al.
PloS one, 14(3), e0213252-e0213252 (2019-03-07)
Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs with naturally-occurring spinal cord injury; safety trials
Mary-Louise Rogers et al.
Journal of neuroimmunology, 226(1-2), 93-103 (2010-06-16)
The common neurotrophin receptor P75NTR, its co-receptor sortilin and ligand proNGF, have not previously been investigated in Natural Killer (NK) cell function. We found freshly isolated NK cells express sortilin but not significant amounts of P75NTR unless exposed to interleukin-12
Darren Carwardine et al.
PloS one, 12(12), e0188967-e0188967 (2017-12-12)
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix
Darren Carwardine et al.
Journal of the neurological sciences, 367, 311-318 (2016-07-18)
A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an

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