ABT112
Anti-Lysyl Oxidase (LOX) Antibody
from rabbit, purified by affinity chromatography
Synonyme(s) :
Protein-lysine 6-oxidase, Lysyl oxidase
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
mouse, human
Réactivité de l'espèce (prédite par homologie)
rat (based on 100% sequence homology)
Technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... LOX(4015)
Description générale
Lysyl Oxidase (Protein-lysine 6-oxidase; LOX) is a member of the lysyl oxidase family and a product of the LOX gene. Lysyl oxidase is an extracellular-matrix oxidative enzyme characterized by its C-terminal LOX catalytic domain. In the presence of copper, lysyl oxidase removes amine groups from lysine residues of target substrates which include precursors of collagen and elastin. This deamination reaction produces reactive lysine residues which can then interact with similarly activated species to form covalent cross-links. Lysyl oxidase is found predominantly in the kidney, pancreas, heart, skeletal muscle, and placenta. Defective lysyl oxidase proteins play a role in cutis laxa autosomal recessive type 1 condition. Other studies have also suggested that lysyl oxidase may also be involved in intracellular signaling and may function as a tumor suppressor.
Immunogène
KLH-conjugated linear peptide corresponding to Lysyl Oxidase (LOX).
Application
Analyse par immunohistochimie : A 1:100 dilution from a representative lot detected Lysyl Oxidase (LOX) in adenocarcinoma cells of human prostate tissues.
Anti-Lysyl Oxidase (LOX) Antibody is an antibody against Lysyl Oxidase (LOX) for use in Western Blotting, IHC(P).
Qualité
µ
Description de la cible
Poids réel (observé) : env. 46 kDa
Autres remarques
Concentration : pour connaître la concentration spécifique du lot, voir le certificat d'analyse.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Miller, BW; Morton, JP; Pinese, M; Saturno, G; Jamieson, NB; McGhee, E; Timpson, P; Leach et al.
EMBO Molecular Medicine null
Heyong Yin et al.
Biomedical materials (Bristol, England), 13(3), 034107-034107 (2018-02-09)
Thermosensitive hydrogels have been studied for potential application as promising alternative cell carriers in cell-based regenerative therapies. In this study, a thermosensitive butane diisocyanate (BDI)-collagen hydrogel (BC hydrogel) was designed as an injectable cell delivery carrier of tendon stem/progenitor cells
Masaru Kaku et al.
Journal of cellular physiology, 231(4), 926-933 (2015-09-19)
Type I collagen, a major extracellular component of the periodontal ligament (PDL), is post-translationally modified by a series of specific enzymes. Among the collagen-modifying enzymes, lysyl oxidase (LOX) is essential to initiate collagen cross-linking and lysyl hydroxylases (LHs) to regulate
Rolf Schreckenberg et al.
Frontiers in physiology, 8, 556-556 (2017-08-22)
Purpose: According to the current therapeutic guidelines of the WHO physical activity and exercise are recommended as first-line therapy of arterial hypertension. Previous results lead to the conclusion, however, that hearts of spontaneously hypertensive rats (SHR) with established hypertension cannot
Rohit Shetty et al.
Molecular vision, 21, 12-25 (2015-01-17)
Keratoconus (KC) is characterized by progressive vision loss due to corneal thinning and structural abnormalities. It is hypothesized that KC is caused by deregulated collagen levels and collagen fibril-maturating enzyme lysyl oxidase (LOX). Further, it is currently not understood whether
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