AB3598
Anti-Mitochondria Antibody
serum, Chemicon®
Synonyme(s) :
Anti-ACNINV3, Anti-FAD, Anti-PS-1, Anti-S182
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
monkey, human
Fabricant/nom de marque
Chemicon®
Technique(s)
immunocytochemistry: suitable
western blot: suitable
Entrée
sample type neural stem cell(s)
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TOMM20L(387990)
Description générale
Presenilin 1 is a protein found in brain cells. Presenilin 1 has a major influence on the risk of contracting alzheimer′s disease. Its function is unknown. However, it may be involved in protein production and trafficking, especially during early development. More than 40 different mutations have been found in the presenilin 1 gene, and these mutations associate with early-onset familial alzheimer′s disease. Mutations in presenilin 1 tend to elevate levels of amyloid beta in the blood, cerebrospinal fluid, and brains of those affected by mutations
Spécificité
Mitochondria. Recognizes a 62 kD protein of immunoblots of subcellular fractions enriched in mitochondrial fractions.
The antibody shows a moderate titer by ELISA to the immunogen peptide but does not immunoblot any expected presenilin 1 bands. Immunocytochemistry with the serum revealed a mitochondria-like staining that was still present after exhaustive preabsorption with the peptide. The staining co-localizes with CHEMICON′s anti-mitochondria antibody MAB1273.
The antibody shows a moderate titer by ELISA to the immunogen peptide but does not immunoblot any expected presenilin 1 bands. Immunocytochemistry with the serum revealed a mitochondria-like staining that was still present after exhaustive preabsorption with the peptide. The staining co-localizes with CHEMICON′s anti-mitochondria antibody MAB1273.
Immunogène
Presenilin 1 peptide conjugated to KLH.
Application
Anti-Mitochondria Antibody is an antibody against Mitochondria for use in WB & IC.
Immunoblotting: 1:500-1:1000
Immunocytochemistry: 1:100-1:300 on COS7, HeLa, 293 and SK-N-MC cell lines.
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:100-1:300 on COS7, HeLa, 293 and SK-N-MC cell lines.
Optimal working dilutions must be determined by the end user.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Neural Stem Cells
Neural Stem Cells
Description de la cible
62 kDa
Forme physique
Rabbit serum preabsorbed against immunogen peptide. Liquid. Contains 0.01% sodium azide.
Stockage et stabilité
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze-thaw cycles.
Remarque sur l'analyse
Control
HeLa whole cell extract, human neuroblastoma SH-SY5Y cells
HeLa whole cell extract, human neuroblastoma SH-SY5Y cells
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
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A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens.
Christopher L Yankaskas et al.
Nature biomedical engineering, 3(6), 452-465 (2019-05-08)
The challenge of predicting which patients with breast cancer will develop metastases leads to the overtreatment of patients with benign disease and to the inadequate treatment of aggressive cancers. Here, we report the development and testing of a microfluidic assay
Wei Wu et al.
Oncotarget, 7(16), 22819-22833 (2016-03-25)
Retinal pigment epithelium (RPE) transplantation is a particularly promising treatment of retinal degenerative diseases affecting RPE-photoreceptor complex. Embryonic stem cells (ESCs) provide an abundant donor source for RPE transplantation. Herein, we studied the time-course characteristics of RPE cells derived from
Kang Chi et al.
Cell transplantation, 27(3), 456-470 (2018-05-15)
Parkinson's disease (PD) causes motor dysfunction and dopaminergic cell death. Drug treatments can effectively reduce symptoms but often cause unwanted side effects. Stem cell therapies using cell replacement or indirect beneficial secretomes have recently emerged as potential therapeutic strategies. Although
Yongwoo Yoon et al.
Stem cells (Dayton, Ohio), 38(8), 936-947 (2020-05-07)
Huntington's disease (HD) is a devastating, autosomal-dominant neurodegenerative disease, for which there are currently no disease-modifying therapies. Clinical trials to replace the damaged striatal medium spiny neurons (MSNs) have been attempted in the past two decades but have met with
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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