567727

D-erythro-Sphingosine-1-phosphate

A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway.

• Synonyme(s) : D-erythro-Sphingosine-1-phosphate
• Formule empirique (notation de Hill): C₁₈H₃₈NO₅P
• Numéro CAS: 26993-30-6
• Poids moléculaire : 379.47
• Numéro MDL: MFCD00270077
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: methanol: 0.5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
• Clé InChI: DUYSYHSSBDVJSM-KRWOKUGFSA-N

Description

Description générale

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃ independent pathway. Activates phospholipase D and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss 3T3 fibroblasts.

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃-independent pathway. Activates phospholipase D (PLD) and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss/3T3 fibroblasts. Inhibits activation of caspases that cleave PARP and lamins during Fas- and ceramide-mediated apoptosis.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Mobilizes calcium from intracellular stores

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Notes préparatoires

Slight warming and vortexing may be required.

Reconstitution

Following reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20°C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20°C.

Autres remarques

Cuvillier, O., et al. 1998. J. Biol. Chem. 273, 2910.
Mattie, M., et al. 1994. J. Biol. Chem.269, 3181.
Olivera, A. and Spiegel, S. 1993. Nature365, 557.
Desai, N.N., et al. 1992. J. Biol. Chem.267, 23122.
Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 9686.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable